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Christian Hauptmann

Coordinated reset neuromodulation for deep brain stimulation – neurotechnology and pre-clinical results


C. Hauptmann1, P. Tass1,2

1 Institute for Neuroscience and Medicine – INM-7, Forschungszentrum Jülich GmbH, Jülich, Germany

2 Department of Neuromodulation, University of Cologne, Cologne, Germany

In the past decade deep brain stimulation (DBS) - the application of electrical stimulation to specific target structures via implanted depth electrodes - has become the standard treatment for medically refractory Parkinson’s disease and essential tremor. These diseases are characterized by pathological synchronized neuronal activity in particular brain areas. Coordinated reset neuromodulation – a stimulation technique developed using a model-based approach- intends to specifically counteract excessive neuronal synchronization and to induce a cumulative unlearning of pathological synaptic connectivity and neuronal synchrony [1-3]. To enable the pre-clinical and clinical investigation of coordinated reset neuromodulation we developed a dedicated implantable pulse generator capable. We present the device and first pre-clinical results obtained with CR in MPTP treated non-human primates, a well established animal model of Parkinson’s disease [4]. The pre-clinical results will be compared with our findings from computer simulations.

Acknowledgements

The pre-clinical study was funded by the Michael J. Fox Foundation, New York (Rapid Response Innovation Award grant to WGM and PAT). Additional support was received from the Deutsche Forschungsgemeinschaft (KFO 219 TA203/ 4-1) and ANM Neuromodulation GmbH (Germany) provided infrastructural support.

References

1. Tass P A 2003 A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations. Biol. Cybern. 89: 81–8

2. Tass P A and Majtanik M 2006 Long-term anti-kindling effects of desynchronizing brain stimulation: a theoretical study. Biol Cybern 94: 58–66

3. Hauptmann C and Tass P A 2007 Therapeutic rewiring by means of desynchronizing brain stimulation. Biosystems 89: 173–81

4. Tass P A, Qin L, Hauptmann C, Dovero S, Bezard E, Boraud T, Meissner W G 2012 Coordinated Reset has sustained after-effects in parkinsonian monkeys. Annals of Neurology 72(5): 816-820